منابع مشابه
A theme series on physical biology in cancer in AJP-Cell.
TISSUE MORPHOGENESIS relies on the autonomy and versatility of individual cells to proliferate and maintain tissue homeostasis. The information content of the genome gives rise to cellular plasticity as a result of the spatial and temporal cues that cells receive from the microenvironment. Physical cues from the microenvironment are translated into biochemical signals; however, environmental or...
متن کاملAJP-Cell begins a theme series on tissue fibrosis.
FIBROSIS IS A COMMON RESPONSE of tissues to chronic injury. Following acute injury, tissue repair is promoted by an intricate inflammatory reaction and matrix remodeling process. In contrast, chronic inflammatory injury results in exaggerated and dysregulated wound healing, characterized by an imbalance between excessive synthesis of extracellular matrix (ECM, comprising collagens and other pro...
متن کاملThe UPR for cytokinesis
A stress-coping strategy of the ER is needed in every cell cycle, show Bicknell et al. (page 1017). The ER’s unfolded protein response (UPR), previously associated only with unusual or stressful conditions, is needed for the routine event of cytokinesis. The UPR is activated when the ER is overloaded with misfolded proteins. It increases ER capacity and helps reduce the load. But the authors wo...
متن کاملUnpicking the UPR.
Mutations in rhodopsin that lead to protein misfolding are a major cause of retinitis pigmentosa (RP). Cells respond to misfolded proteins in their endoplasmic reticulum (ER) by inducing a transcriptional program known as the ‘‘unfolded protein response’’ (UPR), and the UPR is induced in models of rhodopsin RP. The UPR has three branches that sense protein misfolding and initiate this adaptive ...
متن کاملAmerican Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme.
THIS ISSUE of the American Journal of Physiology-Cell Physiology initiates a new type of series: multiple articles organized around a theme. This first theme is autophagy, a mechanism that has become increasingly recognized as important in health and disease. The existence of autophagy (derived from Greek and meaning “to eat oneself”) was initially surmised from electron microscopic studies in ...
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ژورنال
عنوان ژورنال: Seminars in Cancer Biology
سال: 2015
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2015.04.008